https://nova.newcastle.edu.au/vital/access/ /manager/Index en-au 5 Epidemiology of neonatal early-onset sepsis in a geographically diverse Australian health district 2006-2016 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45202 Streptococcus (GBS) and Escherichia coli (E. coli) have dominated as causes of EOS for five decades. Method: An 11-year retrospective cohort study to determine the epidemiology of EOS. Incidence rates were calculated per 1000 live births. Logistic regression with linear temporal trend and covariates for potential effect modifiers were employed. Blood culture utilisation was determined by examining the rate of babies undergoing blood culture within 72 hours of birth. Results: Among 93,584 live born babies, 65 had confirmed EOS (0.69/1000 live births); 22 term, 43 preterm. Across the 4 largest birth units, the proportion of babies having blood culture within 72 hours of birth varied from 1.9–5.1% for term and 21–35% for preterm babies. The annual change in the EOS rate was significant, OR 0.91 (95% CI, 0.84 to 0.99, p = 0.03). Group B Streptococcus was the most common cause of EOS in term neonates at 0.35/1000 live births (95% CI, 0.07–0.63) in 2006 and 0.1/1000 live births (95% CI, 0–0.2) in 2016. Escherichia coli was the most common cause in preterm babies at 3.4/1000 (95% CI, 0.11–6.76) in 2006 reducing significantly to 1.35/1000 live births (95% CI, -0.07–2.78) by 2016. Conclusions: Escherichia coli and GBS were the most common causes of EOS in preterm and term babies respectively. Rates of all cause term and preterm EOS declined significantly as did preterm sepsis due to E. coli. While rate of sepsis due to early-onset GBS declined, this did not reach significance. Given the high proportion of preterm babies undergoing blood culture, it is unlikely that any EOS events were missed.]]> Wed 26 Oct 2022 19:38:20 AEDT ]]> Group B streptococcal screening, intrapartum antibiotic prophylaxis, and neonatal early-onset infection rates in an Australian local health district: 2006-2016 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45197 Wed 26 Oct 2022 19:37:15 AEDT ]]> Disparities in the incidence of acute myocardial infarction: long-term trends from the Hunter region https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:32642 Wed 24 Nov 2021 15:52:35 AEDT ]]> A targeted and tailored eHealth weight loss program for young women: the Be Positive Be Healthe randomized controlled trial https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:35197 Wed 24 May 2023 12:06:57 AEST ]]> Subsurface behavior of ductile material by particle impacts and its influence on wear mechanism https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:18730 Wed 11 Apr 2018 16:41:03 AEST ]]> Improving the translation of search strategies using the Polyglot Search Translator: a randomized controlled trial https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:40004 Wed 06 Jul 2022 11:14:48 AEST ]]> Psychological characteristics of early stuttering https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:49025 Wed 03 May 2023 12:38:19 AEST ]]> The impact of Indigenous-led programs on alcohol-related criminal incidents: a multiple baseline design evaluation https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:52879 Tue 31 Oct 2023 10:46:40 AEDT ]]> Investigating the Relationship between the Time Constant Ratio and Plug-Flow Behaviour in the Pneumatic Conveyance of Biomass Material https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:54423 Tue 27 Feb 2024 13:50:04 AEDT ]]> Conveying and Construction Machinery https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:41860 Tue 16 Aug 2022 12:19:23 AEST ]]> Single-arm longitudinal study to evaluate a decision aid for women offered Neoadjuvant systemic therapy for operable breast cancer https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:48826 Tue 09 May 2023 10:38:07 AEST ]]> Cost-effectiveness analysis of supervised exercise training in men with prostate cancer previously treated with radiation therapy and androgen-deprivation therapy https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:38927 5 years post-diagnosis). Analysis was undertaken for the 6-month supervised exercise portion of the intervention, which involved 100 men aged between 62 and 85 years, 50 in each arm. The primary outcome was cost per quality-adjusted life-years (QALYs). Results: A 6-month supervised exercise intervention for PCa survivors resulted in an incremental cost-effectiveness ratio of AU$64,235 (2018 AUD) at an incremental cost of AU$546 per person and a QALY gain of 0.0085. At a willingness-to-pay of AU$50,000, the probability that the intervention is cost-effective was 41%. Sensitivity analysis showed that maintenance of benefits via a 6-month home-based intervention, immediately following the supervised intervention, lowered the cost per QALY gained to AU$32,051. Discussion: This is the first cost-effectiveness analysis of exercise for PCa survivors. The intervention was effective, but unlikely to be cost-effective at the generally accepted willingness-to-pay of AU$50,000 per QALY. It is likely that evidence to support cost savings from post-intervention outcomes would reveal greater benefits and contribute to a more comprehensive cost-effectiveness analysis. Future RCTs should incorporate longer follow-up durations and collection of data to support modelling to capture future health benefits. Measures of quality of life or utility more sensitive to the impact of physical activity would also improve future economic evaluations.]]> Tue 08 Mar 2022 11:43:17 AEDT ]]> Hunter and New England diabetes alliance: innovative and integrated diabetes care delivery in general practice https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:46889 Tue 06 Dec 2022 11:20:24 AEDT ]]> Predictors of adherence to a physical activity counseling intervention delivered by exercise physiologists: secondary analysis of the NewCOACH trial data https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:34917 Tue 03 Sep 2019 18:18:26 AEST ]]> Postinjury Multiple Organ Failure in Polytrauma: More Frequent and Potentially Less Deadly with Less Crystalloid https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:54907 15, Abbreviated Injury Scale (AIS) Head < 3 and survived > 48 h. Demographics, physiological and shock resuscitation parameters were collected. The primary outcome was MOF defined by a Denver Score > 3. Secondary outcomes: intensive care unit length of stay (ICU LOS), ventilation days and mortality. Results: Three hundred and forty-seven patients met inclusion criteria (age 48 ± 20; ISS 30 ± 11, 248 (71%) were males and 23 (6.6%) patients died. The 74 (21%) MOF patients (maximum Denver Score: 5.5 ± 1.8; Duration; 5.6 ± 5.8 days) had higher ISS (32 ± 11 versus 29 ± 11) and were older (54 ± 19 versus 46 ± 20 years) than non-MOF patients. Mean daily Denver scores adjusted for age, sex, MOF and ISS did not change over time. Crystalloid usage decreased over the 10-year period (p value < 0.01) and PRBC increased (p value < 0.01). Baseline cumulative incidence of MOF at 28 days was 9% and competing risk analyses showed that incidence of MOF increased over time (subdistribution hazard ratio 1.14, 95% CI 1.04 to 1.23, p value < 0.01). Mortality risk showed no temporal change. ICU LOS increased over time (subdistribution hazard ratio 0.95, 95% CI 0.92 to 0.98, p value < 0.01). Ventilator days increased over time (subdistribution hazard ratio 0.94, 95% CI 0.9 to 0.97, p value < 0.01). Conclusion: The epidemiology of MOF continues to evolve. Our prospective cohort suggests an ageing population with increasing incidence of MOF, particularly in males, with little changes in injury or shock parameters, who are being resuscitated with less crystalloids, stay longer on ICU without improvement in survival.]]> Thu 21 Mar 2024 11:56:18 AEDT ]]> Patient-reported outcomes with neoadjuvant vs adjuvant systemic therapy for operable breast cancer https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:36683 Thu 17 Feb 2022 09:29:01 AEDT ]]> Predictors of Lidcombe Program treatment dropout and outcome for early stuttering https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:41974 Thu 11 Apr 2024 14:52:18 AEST ]]> A model for the layer fraction in horizontal slug flow pneumatic conveying and comparison to the model of konrad https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:24141 Thu 10 Nov 2016 13:49:47 AEDT ]]> Development of design models for the transport of fine powders on air-gravity conveyors https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:24134 Thu 10 Nov 2016 11:15:46 AEDT ]]> Bulk solids flow at the hopper feeder interface with special plane flow configuration https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:51466 Thu 07 Sep 2023 10:44:59 AEST ]]> Development of a constitutive model for erosion based on dissipated particle energy to predict the wear rate of ductile metals https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:35049 −1 to 90 ms⁻¹. The developed model also enables determination of the coefficient of restitution, strain rate, dynamic pressure and some valuable parameters to determine the erosion mechanism.]]> Thu 02 Apr 2020 15:40:37 AEDT ]]> The relationship between mental health disorders and treatment outcomes among adults who stutter https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:7287 Sat 24 Mar 2018 08:42:14 AEDT ]]> Screening for personality disorders among adults seeking speech treatment for stuttering https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:7346 Sat 24 Mar 2018 08:40:15 AEDT ]]> Randomized controlled trial of video self-modeling following speech restructuring treatment for stuttering https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:9689 Sat 24 Mar 2018 08:39:14 AEDT ]]> Prevalence of anxiety disorders among adults seeking speech therapy for stuttering https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:8043 Sat 24 Mar 2018 08:35:03 AEDT ]]> Mood and substance use disorders among adults seeking speech treatment for stuttering https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:9690 Sat 24 Mar 2018 08:33:58 AEDT ]]> The Five Factor Model of personality applied to adults who stutter https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:9691 Sat 24 Mar 2018 08:33:58 AEDT ]]> The use of bulk properties for the prediction of pneumatic conveying performance: current practice and future directions https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:2977 Sat 24 Mar 2018 08:27:56 AEDT ]]> Energy dissipation into ductile surfaces by spherical zirconia bead at different impact conditions during erosion https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:13979 Sat 24 Mar 2018 08:24:41 AEDT ]]> North-American Lidcombe program file audit: replication and meta-analysis https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:14552 Sat 24 Mar 2018 08:19:37 AEDT ]]> Experimental determination of cutting and deformation energy factors for wear prediction of pneumatic conveying pipeline https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:11755 Sat 24 Mar 2018 08:11:41 AEDT ]]> Contemporaneous severity of symptoms and functioning reflected by variations in reporting doctor-diagnosed osteoarthritis https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:19905 Sat 24 Mar 2018 08:03:48 AEDT ]]> Modeling and analysis of solids friction factor for fluidized dense phase pneumatic conveying of powders https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:19910 Sat 24 Mar 2018 08:03:45 AEDT ]]> Long-term consequences of noninjurious and injurious falls on well-being in older women https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:27349 Sat 24 Mar 2018 07:39:38 AEDT ]]> Investigations and modeling of the layer fraction in horizontal slug flow pneumatic conveying https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:29424 Sat 24 Mar 2018 07:36:13 AEDT ]]> The evolution of slug porosity characteristics in horizontal slug flow pneumatic conveying https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:29425 Sat 24 Mar 2018 07:36:13 AEDT ]]> Multimorbidity patterns are differentially associated with functional ability and decline in a longitudinal cohort of older women https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:26512 Sat 24 Mar 2018 07:35:32 AEDT ]]> Effect of particle degradation on electrostatic sensor measurements and flow characteristics in dilute pneumatic conveying https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:30862 Sat 24 Mar 2018 07:26:37 AEDT ]]> Referral for expert physical activity counseling: a pragmatic RCT https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:31054 Sat 24 Mar 2018 07:25:47 AEDT ]]> Power spectral density analysis of pressure fluctuation in pneumatic conveying of powders https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:22859 Sat 24 Mar 2018 07:16:02 AEDT ]]> Effect of Early High-Flow Nasal Oxygen vs Standard Oxygen Therapy on Length of Hospital Stay in Hospitalized Children with Acute Hypoxemic Respiratory Failure: The PARIS-2 Randomized Clinical Trial https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:50299 Sat 15 Jul 2023 12:18:12 AEST ]]> Agreement and reliability of the velocity time integral method and the method of disks to determine stroke volume in preterm infants https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:43044 Mon 12 Sep 2022 12:38:23 AEST ]]> CFD simulation methodology for gas-solid flow in bypass pneumatic conveying - a review https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:30945 Mon 04 Nov 2019 12:44:17 AEDT ]]> A Randomized Trial of Nafamostat for Covid-19 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:55470 Mon 03 Jun 2024 16:14:57 AEST ]]> TMPRSS2 inhibitors for the treatment of COVID-19 in adults: a systematic review and meta-analysis of randomized clinical trials of nafamostat and camostat mesylate https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:55463 Mon 03 Jun 2024 10:08:13 AEST ]]> Three Lidcombe program clinic visit options: a phase II trial https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:37192 Fri 28 Aug 2020 15:51:43 AEST ]]> Prognostic biomarkers in stage IV non-small cell lung cancer (NSCLC): neutrophil to lymphocyte ratio (NLR), lymphocyte to monocyte ratio (LMR), platelet to lymphocyte ratio (PLR) and advanced lung cancer inflammation index (ALI) https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:38007 Fri 23 Jul 2021 15:12:43 AEST ]]> The precursor for nerve growth factor (ProNGF) in thyroid cancer lymph node metastases: correlation with primary tumour and pathological variables https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:36624 Fri 21 Oct 2022 12:10:07 AEDT ]]> Exploring Factors Underlying Ethnic Difference in Age-related Macular Degeneration Prevalence https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:49503 Fri 19 May 2023 12:58:08 AEST ]]> Some theoretical consideration of stress states at the hopper feeder interface https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45723 Fri 04 Nov 2022 09:45:08 AEDT ]]> Where are We Headed? Evidence to Inform Future Football Heading Guidelines https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:52987 Fri 03 Nov 2023 15:58:28 AEDT ]]> The Complexity of Stuttering Behavior in Adults and Adolescents: Relationship to Age, Severity, Mental Health, Impact of Stuttering, and Behavioral Treatment Outcome https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:51347 Fri 01 Sep 2023 13:36:37 AEST ]]>